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Thursday, May 17, 2012

Scott Walker leads new Wisconsin recall poll

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Wednesday, May 16, 2012

Total Vibration ? Blog Archive ? Fear Of Commitment In Relationships

Fear of dedication scientifically, is a type of phobia. It?s generally referred to as as the commitment phobia which refers to an individual who is afraid of being committed to any deep relationships, duties, projects and responsibilities.

Have you ever ever know somebody who has the worry of dedication? I?ve several buddies who?ve the signs of this kind of phobia. Most of them are men. They can not determine on easy things. They find it onerous to decide on on what to eat throughout a dine-out in a restaurant, they can not choose between good films, even on what to wear. And worst no considered one of them has ever been to critical relationships, considering the fact that they are already of their 30?s and is a perfect marrying age for men.

Let me let you know about my good friend named Patrick. He is considered one of my closest pals and he?s a bachelor who makes good money. Girls are coming out and in of his life just like the wind. And nobody seems to final even the ones that I think would last. I suspected that he has worry of commitment. However he won?t accept it, which actually is one other characteristic of an individual who has a concern of commitment. We had a conversation about it once. Here it goes:

Me: ?Have you ever been to a serious relationship before? Patrick: ?Nope.? Re replied. Me: ?Why?? Patrick: ?It is because I?m not ready yet.? Me: ?What are the issues that made you not prepared? I asked again. He simply shrugged his shoulders and paused. Patrick: ?It?s just because I am afraid to decide to a woman, and I do not wish to get married at this time. I am afraid that I could not handle the responsibilities of a father and a husband on the identical time.? Me: ?Then you?re a kind of who?re afraid of commitments or the fear of commitment.? Patrick: ?Am I? I do not assume so.?

Concern of dedication makes it arduous so that you can decide on whatever it is advisable to decide on especially if the future is at stake. Subsequently, having a worry of dedication is just not healthy at all. Fear of commitment can actually maintain you again as a result of it is just be entrusting to a process that life has to supply and we?re capable of benefit from opportunities that come our way.

Fear of dedication will be triggered by various causes. Concern of commitment could start from childhood from which a person suffered from traumatic expertise, comparable to separation of fogeys, divorce, and death. Worry of dedication can be a result of poor function fashions in which the particular person may have witnessed offensive relationships. And worst the individual could have been a sufferer of it. These experiences have an important impact on the individual?s determination making and therefore the cause of growth of their concern of commitment.

Fear of Commitment though will be defeated by completely different methods. The commonest methodology utilized in overcoming worry of Dedication is the hypnosis or hypnotherapy. So if in case you have friends who?re affected by a dedication phobia or concern of dedication, assist them defeat it.

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Evernote updated to v4.0 - Brings redesigned Home Screen, with improved note and notebook lists

Evernote

Now that Android 4.0 Ice Cream sandwich is spreading we've seen a lot of apps get UI updates to conform a little better to Google's design philosophy and now, we can add Evernote into that group. The latest update available in the Google Play Store brings a whole new design to Evernote along with plenty of changes for the better:

  • A redesigned Home Screen, with improved note and notebook lists across the app
  • Responsive Action and Navigation Bars, which relate to the screen you're viewing and disappear for easy reading or note viewing
  • Swipe navigation horizontally to scan through Notebooks, Tags and Places easily
  • Location tagging for all your notes, if your phone is "Location Services" enabled

Aside from the visual changes, Evernote has worked plenty on the engine below the surface that powers the app. You'll find plenty of bug fixes and improvements overall. If you're looking to see it in action before giving it a go, you'll find a video below along with the download link.

Source: Evernote

read more



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Tuesday, May 15, 2012

Chemotherapy's effect on overall survival seems to increase based on tumor size

Chemotherapy's effect on overall survival seems to increase based on tumor size [ Back to EurekAlert! ] Public release date: 15-May-2012
[ | E-mail | Share Share ]

Contact: Kristal Griffith
Kristal.Griffith@IASLC.org
720-325-2952
International Association for the Study of Lung Cancer

Authors draw no specific recommendations due to size of study

DENVER The most recent research released in June's Journal of Thoracic Oncology indicates there might be a positive correlation between tumor size and adjuvant platinum based chemotherapy in surgically resected patients with node negative non-small cell lung cancer. The study, published in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, analyzed the effect of tumor size and KRAS mutations on survival benefit from adjuvant platinum based chemotherapy in patients with node negative non-small cell lung cancer.

The purpose of the retrospective study was to apply the most current, 7th edition, TNM staging system, to a retrospective cohort of surgically resected, node negative, non-small cell lung cancer patients who were treated with adjuvant platinum based chemotherapy. Previous clinical trials confirmed a survival benefit for adjuvant platinum based chemotherapy for patients with stage II-IIIa non-small cell lung cancer. In addition, the authors explored the interaction between tumor size and KRAS mutations in predicting a benefit from the chemotherapy.

After analyzing data from 461 patients that were part of two previous adjuvant trials, JBR.10 and CALBG 9633, the authors found a positive correlation between the size of the tumor and efficacy of chemotherapy with respect to disease free survival. There was no clear demarcation of what T size threshold correlated with benefit of chemotherapy. KRAS mutation was detected in 27 percent of the specimens, correlated with a worse prognosis but not with the size of the tumor.

"Thus, our study reinforces the pressing need for improved understanding of the impact of the new T-size descriptors on adjuvant chemotherapy effect," the authors say. "This is particularly valid when we consider that up to 77 percent of surveyed lung cancer physicians would alter patient management in response to a change in stage designation."

###

The lead author of this work is IASLC member Dr. Sinead Cuffe. Other IALSC co-authors include: Dr. Frances Shepherd, Dr. Jean-Pierre Pignon, Dr. Lesley Seymour, Dr. Ronald Burkes, Dr. Pasi Janne and Dr. Ming Tsao.

About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit www.iaslc.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Chemotherapy's effect on overall survival seems to increase based on tumor size [ Back to EurekAlert! ] Public release date: 15-May-2012
[ | E-mail | Share Share ]

Contact: Kristal Griffith
Kristal.Griffith@IASLC.org
720-325-2952
International Association for the Study of Lung Cancer

Authors draw no specific recommendations due to size of study

DENVER The most recent research released in June's Journal of Thoracic Oncology indicates there might be a positive correlation between tumor size and adjuvant platinum based chemotherapy in surgically resected patients with node negative non-small cell lung cancer. The study, published in the June 2012 issue of the International Association for the Study of Lung Cancer's (IASLC) Journal of Thoracic Oncology, analyzed the effect of tumor size and KRAS mutations on survival benefit from adjuvant platinum based chemotherapy in patients with node negative non-small cell lung cancer.

The purpose of the retrospective study was to apply the most current, 7th edition, TNM staging system, to a retrospective cohort of surgically resected, node negative, non-small cell lung cancer patients who were treated with adjuvant platinum based chemotherapy. Previous clinical trials confirmed a survival benefit for adjuvant platinum based chemotherapy for patients with stage II-IIIa non-small cell lung cancer. In addition, the authors explored the interaction between tumor size and KRAS mutations in predicting a benefit from the chemotherapy.

After analyzing data from 461 patients that were part of two previous adjuvant trials, JBR.10 and CALBG 9633, the authors found a positive correlation between the size of the tumor and efficacy of chemotherapy with respect to disease free survival. There was no clear demarcation of what T size threshold correlated with benefit of chemotherapy. KRAS mutation was detected in 27 percent of the specimens, correlated with a worse prognosis but not with the size of the tumor.

"Thus, our study reinforces the pressing need for improved understanding of the impact of the new T-size descriptors on adjuvant chemotherapy effect," the authors say. "This is particularly valid when we consider that up to 77 percent of surveyed lung cancer physicians would alter patient management in response to a change in stage designation."

###

The lead author of this work is IASLC member Dr. Sinead Cuffe. Other IALSC co-authors include: Dr. Frances Shepherd, Dr. Jean-Pierre Pignon, Dr. Lesley Seymour, Dr. Ronald Burkes, Dr. Pasi Janne and Dr. Ming Tsao.

About the IASLC:

The International Association for the Study of Lung Cancer (IASLC) is the only global organization dedicated to the study of lung cancer. Founded in 1974, the association's membership includes more than 3,500 lung cancer specialists in 80 countries. To learn more about IASLC please visit www.iaslc.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Factbox: Early Facebook backers and their bets today

(Reuters) - Facebook's earliest venture-capital backers, especially at once-downtrodden outfit Accel Partners, will have reason to celebrate come Friday when the world's biggest social network is set to debut on the Nasdaq at as much as a $100 billion valuation.

Here is a look at some of these pioneering investors and what they are looking at now.

KEVIN EFRUSY, ACCEL PARTNERS

Efrusy did research and sourced Accel's original investment in Facebook, although Accel partner Jim Breyer sits on Facebook's board. Since then, Efrusy has invested in businesses ranging from deal-a-day company Groupon to financing company Capital Access Networks.

Currently, he spends a lot of time on flights to Brazil, where he made several investments last year, including: online travel site Despegar; brain-development company Mind Lab; online retailer Shoes4You; and online craft marketplace Elo7.

CHI-HUA CHIEN, KLEINER PERKINS

Chien was an associate at Accel Partners while getting an MBA at Stanford University, told the partners at Accel about Facebook, and did some research that led to Accel's investment.

In 2007, Chien joined Kleiner Perkins, which has a number of high-profile consumer-Internet investments, many handled by Chien. The firm made an investment in Facebook around early 2011, a spokeswoman for Kleiner Perkins said. Chien was involved in Kleiner's investment in microblogging service Twitter, and sits on the boards of influence-gauging service Klout, social-network Path, and proximity-based marketing service Zaarly.

One departure from his consumer-Internet focus is Home Value Protection, which insures homeowners against falling home values. The investment was inspired in part after watching fellow Californians struggle to hold onto homes in the early 1990s recession as well as today, he said.

MATT COHLER, BENCHMARK PARTNERS

Cohler left a job at LinkedIn in early 2005 to become Facebook's seventh employee. In 2008, he left to join Benchmark Capital, which has not invested in Facebook.

At Benchmark, he has invested in a couple of companies run by Facebook chums. They include business-collaboration service Asana, co-founded by Facebook alumni Dustin Moskovitz and Justin Rosenstein, and question-and-answer service Quora, founded by Facebook alumni Charlie Cheever and Adam D'Angelo.

He also led Benchmark's investment in photo-sharing service Instagram, which Facebook bought last month for $1 billion.

But he is also thinking farther afield. Cohler has invested in China-based Baixing, an online community and marketplace; Germany-based ResearchGate, a social network for scientists; and Brazilian deal service Peixe Urbano.

PAUL MADERA, MERITECH CAPITAL

Madera used to fly F-16s as a U.S. Air Force pilot. His introduction to finance came via stints at Morgan Stanley and Montgomery Securities before co-founding Meritech in 1999.

Normally, the firm gets involved in a start-up company's later stages, expecting a return of three times capital, much lower than the 10 times or so earlier-stage venture capital firms seek.

Madera's eclectic background has resulted in investments to match. Some of his other bets include: DealerSocket, a customer-relations management service for auto dealers; Glaukos, a glaucoma-specialized medical-services company; Wonga, a British short-term consumer-loans company; and Yammer, a social-network for business.

DAVID SZE, GREYLOCK PARTNERS

At the time he made his Facebook investment, Sze already had several years as a partner at Greylock under his belt, allowing him to invest in business social-network LinkedIn.

Today, he is investing in companies such as Path, the social network founded by Facebook alumnus Dave Morin, and WhoSay, which handles personal media management for celebrities, and is quick to tip his hat to the overall Greylock team.

"We don't do anything in isolation," he said. "It's a gang tackle."

Before joining Greylock, he did stints at Internet-services and content company Excite, Inc. and games company Electronic Arts. His sister is artist Sarah Sze, who is representing the United States at the Venice Biennale art fair next year.

(This story corrects 6th graf to say Kleiner Perkins made an investment in Facebook.)

(Reporting By Sarah McBride; Editing by Will Dunham)

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